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Publications

 

 

 

• Pérez-Vargas J, Lemieux G, Thompson CAH, Désilets A, Ennis S, Gao G, Gordon DG, Schulz AL, Niikura M, Nabi IR, Krajden M, Boudreault PL, Leduc R, Jean F (2024) Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals. Antiviral Res. Mar 26:225:105869.

• Le Moal E, Liu Y, Collerette-Tremblay J, Dumontier S, Fabre P, Molina T, Dort J, Orfi Z, Denault N, Boutin J, Michaud J, Giguère H, Desroches A, Trân K, Ellezam B, Vézina F, Bedard S, Raynaud C, Balg F, Sarret P, Boudreault PL, Scott MS, Denault JB, Marsault E, Feige JN, Auger-Messier M, Dumont NA, Bentzinger CF (2024) Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice. Sci Transl Med. Mar 20;16(739):eabn8529.

 

• Huy ML, Desgagné M, Nguyen DT, Comeau Froehlich U, Marsault E, Boudreault P-L* (2024) Insights on Structure-Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles. J Med Chem Feb 28.

 

• Langlois J-P, Larose A, Brouillette E, Delbrouck JA, Boudreault P-L, Malouin F* (2024) Mode of Antibacterial Action of Tomatidine C3-Diastereoisomers. Molecules Jan 10:29(2):343.

Colombo E, Désilets A, Hassanzadeh H, Lemieux G, Marois I, Cliche D, Delbrouck JA, Murza A, Jean F, Marsault E, Richter MV, Leduc R, Boudreault PL* (2024) Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication. ChemMedChem Jan15:19(2):e202300458.

Cover Page ChemMedChem Volume 19, Issue 2, January 15, 2024 (PDF)

• Langlois J-P, Larose A, Brouillette E, Delbrouck JA, Boudreault P-L, Malouin F* (2024) Mode of Antibacterial Action of Tomatidine C3-Diastereoisomers. Molecules Jan 10:29(2):343.

• Ferková S, Froehlich U, Nepveu-Traversy M-E, Murza A, Azad T, Grandbois M, Sarret P, Lavigne P, Boudreault PL* (2023) Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. Int J Mol Sci Dec 21:25(1):166.

• Delbrouck JA, Murza A, Diachenko I, Ben Jamaa A, Devi R, Larose A, Chamberland S, Malouin F*, Boudreault PL* (2023) From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance. Eur J Med Chem Dec 15:262:115886.

 

Pérez-Vargas J, Shapira T, Olmstead AD, Villanueva I,  Thompson CAH, Ennis S,  Gao1 G, DeGuzman J, Williams DE, Wang M, Chin A, Bautista-Sánchez A, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha P, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ*, Jean F*, (2023) A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerging Microbes & Infections. 12:2246594.

• Robillard S, Trân K, Lachance MS, Brazeau T, Boisvert E, Lizotte E, Auger-Messier M, Boudreault PL, Marsault E, Geraldes P (2023) Apelin prevents diabetes-induced poor collateral vessel formation and blood flow reperfusion in ischemic limb. Frontiers in Cardiovascular Medicine, 10:1191891

• Millette G, Lacasse E, Binette R, Belley V, Chaumont LP, Ster C, Beaudry F, Boyapelly K, Boudreault PL, Malouin F (2023) Rationally Designed Pyrimidine Compounds: Promising Novel Antibiotics for the Treatment of Staphylococcus aureus-Associated Bovine Mastitis. Antibiotics, 12(8):1344

• Loubane G, Robert G, Firdaus SB, Venne P, Comeau C, Boudreault PL, Komba JE, Wagner JR, Naylor S, Klarskov K (2023) Conundrum of dehydroascorbic acid and homocysteine thiolactone reaction products: Structural characterization and effect on peptide and protein N-homocysteinylation. Free Radic Biol Med, 206:111-124

• Delbrouck JA, Desgagné M, Comeau C, Bouarab K, Malouin F, Boudreault PL (2023) The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review. Molecules, 28(13):4957

• L'Exact M, Comeau C, Bourhis A, Boisvert O, Froehlich U, Létourneau D, Marsault E, Lavigne P, Grandbois M, Boudreault PL (2023) Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles. Biochim Biophys Acta Biomembr, 1865(7):1841

Laniel A, Marouseau E, Nguyen DT, Froehlich, U, McCartney C, Boudreault PL*, Lavoie C* (2023) Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis. Molecular Pharmaceutics, 20(3):1577-1590.

 

Théroux L, Van Den Hauwe R, Trân K, Fournier J, Desgagné M, Meneboo N, Lavallée A, Fröhlich U, Côté J, Hollanders C, Longpré JM, Murza A, Marsault E, Sarret P*, Boudreault PL*, Ballet S*, (2023) Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13. ACS Pharmacology & Translational Science, 6(2):290-305.

• Pérez-Vargas J, Shapira T, Olmstead AD, Villanueva I,  Thompson CAH, Ennis S,  Gao1 G, DeGuzman J, Williams DE, Wang M, Chin A, Bautista-Sánchez A, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha P, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ*, Jean F*, (2023) Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics. Antiviral Research. 209:105484.

 

Binette R, Desgagné M, Theaud C, Boudreault PL, (2022) Efficient Fmoc-Protected Amino Ester Hydrolysis Using Green Calcium(II) Iodide as a Protective Agent. Molecules. 27(9):2788

Shapira T, Monreal IA, Jager M, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M, Vandal T, Thompson CAH, Chin A, Rees WD, Steiner T, Nabi IR, Marsault E, Sahler J, Diel GD, Van de Walle GR, August A, Whittaker GR, Boudreault PL, Leduc R, Aguilar HC, Jean F. (2022) A TMPRSS2 inhibitor acts as a pan-SARS-Cov-2 prophylactic and therapeutic. Nature. 605(7909):340-348.

 

Trân K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy E, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault E, Boudreault PL, Sarret P. (2022) Size-​Reduced Macrocyclic Analogues of [Pyr1]​-​apelin-​13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects. Journal of Medicinal Chemistry. 65(1):531-551.

Normandin C, Boudreault PL. (2021) Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product. Molecules. 26(19):6008.

 

Chartier, M; Desgagné, M; Sousbie, M; Rumsby, C; Chevillard, L; Théroux, L; Haroune, L; Côté, J;-Longpré, JM; Boudreault, PL; Marsault, E; Sarret, P;. (2021). Pharmacodynamic and Pharmacokinetic Profiles of a Neurotensin Receptor Type 2 (NTS2) Analgesic Macrocyclic Analog. Biomedicine & Pharmacotherapy. 141: 111861.
 

Comeau, C*; Ries, B, Stadelmann, T; Tremblay, J*; Poulet, S*; Froehlich, U; Côté, J; Boudreault, PL; Derbali, RM; Sarret, P; Grandbois, M; Leclair, G; Riniker, S; Marsault, E. (2021). Modulation of the passive permeability of semi-peptidic macrocycles – N-and C-methylations fine-tune conformation and properties. Journal of Medicinal Chemistry. 64(9): 5365-5383.

• Marsault E, Boudreault PL, Traboulsi H, Sarret P, Nepveu-Traversy ME, Gaudreau S, Leduc F, Larrivee JF, Arcand M. (2020) Anti-​human NTSR1 (neurotensin receptor type )​1 antibodies and conjugates for diagnosis and treatment of NTSR1-​associated metabolic or neoplastic disease. Patent WO 2020041896.
 

A Murza, SP Dion, PL Boudreault, A Désilets, R Leduc, E Marsault. (2020). Inhibitors of Type II transmembrane serine proteases in treatment of diseases of the respiratory tract. Expert Opinion on Therapeutic Patents. 30(11): 807-824.
 

Le Roux, A; Blaise, E; Boudreault, PL; Comeau, C; Doucet, A; Giarrusso, M; Collin, MP; Neubauer, T; Koelling, F; Goeller, A; Seep, A; Tshitenge, D; Wittwer, M; Kullmann, M; Hillisch, A; Mittendorf, J; Marsault, E. (2020). Structure-Permeability Relationship of Semi-Peptidic Macrocycles – Understanding and Optimizing Passive Permeability and Efflux Ratio. Journal of Medicinal Chemistry. 63(13): 6774-6783.
 

Béliveau F; Tarkar A; Ghinet MG; Dion SP; Boudreault PL; Désilets A; StGeorges C; Marsault E; Paone D; Collins J; Macphee CH; Campobasso N; Groy A; Cottom J; Ouellette M; Pope AJ; Leduc R. (2019). TMPRSS6 inhibitors increase hepcidin levels in hepatocytes. Cell Chemical Biology. 26(11): 1559-1572.
 

K Klarskov, H Gagnon, PL Boudreault*, C Normandin*, B Plancq*, E Marsault, GJ Gleich, S Naylor. (2018). Structure determination of disease-associated peak AAA from L-tryptophan implicated inthe eosinophiliamyalgia syndrome.Toxicology Letters. 282: 71-80.

Boulet M, Lamontagne C, Guay I, Brouillette E, Langlois JP, Jacques PE, Rodrigue S, Brzezinski R;, Beauregard P, Bouarab K, Boyapelly K, Boudreault PL, Marsault E, Malouin F. (2018) Tomatidine is a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C. Antimicrobial Agents and Chemotherapy, 62(6), e02197-17/1-e02197-17/18.
 

Klarskov K; Gagnon H; Boudreault PL; Racine M; Boudreault PL; Normandin C; Marsault E; Gleich GJ; Naylor S. (2018). Peak AAA fatty acid contaminants present in the dietary supplementL-Tryptophan associated with the onset of Eosinophilia-Myalgia syndrome. Toxicology Letters. 294: 193-204.
 

• Lamontagne Boulet M, Isabelle C, Guay I, Brouillette E, Langlois JP, Jacques PÉ, Rodrigue S, Brzezinski R, Beauregard PB, Bouarab K, Boyapelly K, Boudreault PL, Marsault É, Malouin F. (2018). Tomatidine, a lead antibiotic molecule that targetsStaphylococcus aureus ATP synthase subunit C. Antimicrobial Agents and Chemotherapy. 62(6): e02197-17.

• Leyton JF, Marsault E, Beaudoin S, Boudreault PL, Bonin MA, Lopez A. (2018) Antibody conjugate for treating and detecting bladder cancer. Patent WO 2018165752.

• Boudreault PL, Colombo E, Leduc R, Marsault E, Plancq B, Richter M. (2018) Matriptase inhibitors and therapeutic uses thereof. Patent WO 2018112648.

 

C St-Georges*, A Désilets, F Béliveau, M Ghinet, SP Dion, É Colombo*, PL Boudreault, RJ Najmanovich, R Leduc, E Marsault. (2017). Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.European Journal of Medicinal Chemistry. 129: 110-123.

 

M Paquette, L Guillermo Vilera-Perez, S Beaudoin, N Ekindi-Ndongo, PL Boudreault, MA Bonin, MC Battista, M Bentourkia, AF Lopez, R Lecomte, E Marsault, B Guérin, R Sabbagh, JV Leyton. (2017). Targeting IL5Ra with antibody-conjugates reveals a strategy for imaging and therapy forinvasive bladder cancer. Oncoimmunology. 6(10): e1331195.
 

Berube, C; Barbeau, X; Cardinal, S; Boudreault, PL; Bouchard, C; Delcey, N; Lague, P; Voyer, N. (2017). Interfacialsupramolecular biomimetic epoxidation catalyzed by cyclic dipeptides. Supramolecular Chemistry. 29(5): 330-349.
 

Berube, C; Cardinal, S; Boudreault, PL; Barbeau, X; Delcey, N; Giguere, M; Gleeton, D; Voyer, N (2015). Novel chiralN,N'-dimethyl-1,4-piperazines with metal binding abilities. Tetrahedron. 71(42): 8077-8084.

 

Boudreault, PL; Mattler, JK; Wender, PA. (2015). Studies on the regio-and diastereo-selective epoxidation of daphnanes and tiglianes. Tetrahedron Letters. 56(23): 3423-3427.

 

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R. (2014). Analysis of subpocketselectivity and identification of potent selective inhibitors for matriptaseand matriptase-2. Journal of Medicinal Chemistry. 57(23): 10198-204.

Boudreault PL, Arseneault M, Otis F, Voyer N. (2008). Nanoscale tools to selectively destroy cancer cells. Chemical Communications, (18), 2118-20.

 

Boudreault PL, Voyer N. (2007). Synthesis, characterization and cytolytic activity of alpha-​helical amphiphilic peptide nanostructures containing crown ethers. Organic and Biomolecular Chemistry, 5(9), 1459-65.

 

Autres publications du groupe

Coquerel, D., Lamoureux, J., Chagnon, F., Trân, K., Sage, M., Fortin-Pellerin, E., Delile, E., Sainsily, X., Fournier, J., Dumont, A. A., Auger-Messier, M., Sarret, P., Marsault, E., Praud, J. P., Fülöp, T., & Lesur, O. (2021). Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients. Scientific reports, 11(1), 22770.

 

Sainsily, X., Coquerel, D., Giguère, H., Dumont, L., Tran, K., Noll, C., Ionescu, A. L., Côté, J., Longpré, J. M., Carpentier, A., Marsault, É., Lesur, O., Sarret, P., & Auger-Messier, M. (2021). Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake. Frontiers in pharmacology, 12, 709467.

Trân, K., Van Den Hauwe, R., Sainsily, X., Couvineau, P., Côté, J., Simard, L., Echevarria, M., Murza, A., Serre, A., Théroux, L., Saibi, S., Haroune, L., Longpré, J. M., Lesur, O., Auger-Messier, M., Spino, C., Bouvier, M., Sarret, P., Ballet, S., & Marsault, É. (2021). Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. Journal of medicinal chemistry, 64(9), 5345–5364.

Coquerel, D., Delile, E., Dumont, L., Chagnon, F., Murza, A., Sainsily, X., Salvail, D., Sarret, P., Marsault, E., Auger-Messier, M., & Lesur, O. (2021). Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats. American journal of physiology. Heart and circulatory physiology, 320(4), H1646–H1656.

Chartier, M., Desgagné, M., Sousbie, M., Côté, J., Longpré, J. M., Marsault, E., & Sarret, P. (2021). Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic. Journal of medicinal chemistry, 64(4), 2110–2124.

Trân, K., Murza, A., Sainsily, X., Delile, E., Couvineau, P., Côté, J., Coquerel, D., Peloquin, M., Auger-Messier, M., Bouvier, M., Lesur, O., Sarret, P., & Marsault, É. (2021). Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. Journal of medicinal chemistry, 64(1), 602–615.

Langlois, J. P., Millette, G., Guay, I., Dubé-Duquette, A., Chamberland, S., Jacques, P. É., Rodrigue, S., Bouarab, K., Marsault, É., & Malouin, F. (2020). Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus. Frontiers in microbiology, 11, 805.

Brouillette, R. L., Besserer-Offroy, É., Mona, C. E., Chartier, M., Lavenus, S., Sousbie, M., Belleville, K., Longpré, J. M., Marsault, É., Grandbois, M., & Sarret, P. (2020). Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Pharmacological research, 155, 104750.

Marsault, E., Llorens-Cortes, C., Iturrioz, X., Chun, H. J., Lesur, O., Oudit, G. Y., & Auger-Messier, M. (2019). The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders. Annals of the New York Academy of Sciences, 1455(1), 12–33.

Simmons, J. R., Murza, A., Lumsden, M. D., Kenward, C., Marsault, É., & Rainey, J. K. (2019). Simultaneous Ligand and Receptor Tracking through NMR Spectroscopy Enabled by Distinct 19F Labels. International journal of molecular sciences, 20(15), 3658.

Sousbie, M., Vivancos, M., Brouillette, R. L., Besserer-Offroy, É., Longpré, J. M., Leduc, R., Sarret, P., & Marsault, É. (2018). Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). Journal of medicinal chemistry, 61(16), 7103–7115.

• Murza, A., Trân, K., Bruneau-Cossette, L., Lesur, O., Auger-Messier, M., Lavigne, P., Sarret, P., & Marsault, É. (2018). Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond. Peptide Science, 111(1), e24064.

Besserer-Offroy, É., Bérubé, P., Côté, J., Murza, A., Longpré, J. M., Dumaine, R., Lesur, O., Auger-Messier, M., Leduc, R., Marsault, É., & Sarret, P. (2018). The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. Pharmacological research, 131, 7–16.

Guay, I., Boulanger, S., Isabelle, C., Brouillette, E., Chagnon, F., Bouarab, K., Marsault, E., & Malouin, F. (2018). Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp. BMC pharmacology & toxicology, 19(1), 7.

Coquerel, D., Sainsily, X., Dumont, L., Sarret, P., Marsault, É., Auger-Messier, M., & Lesur, O. (2018). The apelinergic system as an alternative to catecholamines in low-output septic shock. Critical care (London, England), 22(1), 10.

Yan, L. H., Le Roux, A., Boyapelly, K., Lamontagne, A. M., Archambault, M. A., Picard-Jean, F., Lalonde-Seguin, D., St-Pierre, E., Najmanovich, R. J., Fortier, L. C., Lafontaine, D., & Marsault, É. (2018). Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile. European journal of medicinal chemistry, 143, 755–768.

Coquerel, D., Chagnon, F., Sainsily, X., Dumont, L., Murza, A., Côté, J., Dumaine, R., Sarret, P., Marsault, É., Salvail, D., Auger-Messier, M., & Lesur, O. (2017). ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock. Critical care medicine, 45(11), e1139–e1148.

Besserer-Offroy, É., Brouillette, R. L., Lavenus, S., Froehlich, U., Brumwell, A., Murza, A., Longpré, J. M., Marsault, É., Grandbois, M., Sarret, P., & Leduc, R. (2017). The signaling signature of the neurotensin type 1 receptor with endogenous ligands. European journal of pharmacology, 805, 1–13.

Chagnon, F., Coquerel, D., Salvail, D., Marsault, E., Dumaine, R., Auger-Messier, M., Sarret, P., & Lesur, O. (2017). Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Critical care medicine, 45(4), e391–e398.

Murza, A., Sainsily, X., Côté, J., Bruneau-Cossette, L., Besserer-Offroy, É., Longpré, J. M., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., & Marsault, É. (2017). Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Organic & biomolecular chemistry, 15(2), 449–458.

Mona, C. E., Besserer-Offroy, É., Cabana, J., Leduc, R., Lavigne, P., Heveker, N., Marsault, É., & Escher, E. (2016). Design, synthesis, and biological evaluation of CXCR4 ligands. Organic & biomolecular chemistry, 14(43), 10298–10311.

Deny, L. J., Traboulsi, H., Cantin, A. M., Marsault, É., Richter, M. V., & Bélanger, G. (2016). Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway. Journal of medicinal chemistry, 59(20), 9431–9442.

Zoratti, G. L., Tanabe, L. M., Hyland, T. E., Duhaime, M. J., Colombo, É., Leduc, R., Marsault, E., Johnson, M. D., Lin, C. Y., Boerner, J., Lang, J. E., & List, K. (2016). Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. Oncotarget, 7(36), 58162–58173.

Mona, C. E., Besserer-Offroy, É., Cabana, J., Lefrançois, M., Boulais, P. E., Lefebvre, M. R., Leduc, R., Lavigne, P., Heveker, N., Marsault, É., & Escher, E. (2016). Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. Journal of medicinal chemistry, 59(16), 7512–7524.

Murza, A., Sainsily, X., Coquerel, D., Côté, J., Marx, P., Besserer-Offroy, É., Longpré, J. M., Lainé, J., Reversade, B., Salvail, D., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., & Marsault, É. (2016). Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. Journal of medicinal chemistry, 59(7), 2962–2972.

Boulanger, S., Mitchell, G., Bouarab, K., Marsault, É., Cantin, A., Frost, E. H., Déziel, E., & Malouin, F. (2015). Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions. Antimicrobial agents and chemotherapy, 59(12), 7458–7464.

Treder, A. P., Hickey, J. L., Tremblay, M. C., Zaretsky, S., Scully, C. C., Mancuso, J., Doucet, A., Yudin, A. K., & Marsault, E. (2015). Solid-Phase Parallel Synthesis of Functionalised Medium-to-Large Cyclic Peptidomimetics through Three-Component Coupling Driven by Aziridine Aldehyde Dimers. Chemistry (Weinheim an der Bergstrasse, Germany), 21(25), 9249–9255.

Zoratti, G. L., Tanabe, L. M., Varela, F. A., Murray, A. S., Bergum, C., Colombo, É., Lang, J. E., Molinolo, A. A., Leduc, R., Marsault, E., Boerner, J., & List, K. (2015). Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nature communications, 6, 6776.

Traboulsi, H., Larkin, H., Bonin, M. A., Volkov, L., Lavoie, C. L., & Marsault, É. (2015). Macrocyclic cell penetrating peptides: a study of structure-penetration properties. Bioconjugate chemistry, 26(3), 405–411.

Murza, A., Besserer-Offroy, É., Côté, J., Bérubé, P., Longpré, J. M., Dumaine, R., Lesur, O., Auger-Messier, M., Leduc, R., Sarret, P., & Marsault, É. (2015). C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. Journal of medicinal chemistry, 58(5), 2431–2440.

Tremblay, H., St-Georges, C., Legault, M. A., Morin, C., Fortin, S., & Marsault, E. (2014). One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties. Bioorganic & medicinal chemistry letters, 24(24), 5635–5638.

Treder, A. P., Tremblay, M. C., Yudin, A. K., & Marsault, E. (2014). Solid-phase synthesis of piperazinones via disrupted Ugi condensation. Organic letters, 16(17), 4674–4677.

Murza, A., Belleville, K., Longpré, J. M., Sarret, P., & Marsault, É. (2014). Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid. Biopolymers, 102(4), 297–303.

Chagnon, F., Guay, I., Bonin, M. A., Mitchell, G., Bouarab, K., Malouin, F., & Marsault, É. (2014). Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. European journal of medicinal chemistry, 80, 605–620.

Demeule, M., Beaudet, N., Régina, A., Besserer-Offroy, É., Murza, A., Tétreault, P., Belleville, K., Ché, C., Larocque, A., Thiot, C., Béliveau, R., Longpré, J. M., Marsault, É., Leduc, R., Lachowicz, J. E., Gonias, S. L., Castaigne, J. P., & Sarret, P. (2014). Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. The Journal of clinical investigation, 124(3), 1199–1213.

Beaulieu, A., Gravel, É., Cloutier, A., Marois, I., Colombo, É., Désilets, A., Verreault, C., Leduc, R., Marsault, É., & Richter, M. V. (2013). Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium. Journal of virology, 87(8), 4237–4251.

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