We are proud to announce that a multidisciplinary research team, including Professors Pierre-Luc Boudreault and Richard Leduc from Université de Sherbrooke, has developed N-0385 an antiviral that could be considered a new way to protect against COVID-19. Using Computer-Assisted Drug Design, our group at UdeS designed, synthesized and optimized N-0385, the first treatment of its kind with nasal spray proven to be effective against all COVID-19 variants of concern. This collaboration involves Professor François Jean, from the Department of Microbiology and Immunology at the University of British Columbia, and Professors Hector C. Aguilar and Gary Whittaker, from Cornell University, experts in experimentation in a level 3 containment laboratory, necessary for the study of SARS-CoV-2. This major discovery was published in the prestigious journal Nature.